Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules
TP53-inducible gene 5 protein <p>This subsection of the <a href=http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection>Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation a Tumor protein P53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as.
TP53: Tumor protein p53: TP53INP1: Tumor protein p53 inducible nuclear protein 1: TP53TG3: TP53 target 3: TP53RK: TP53 regulating kinase: TP53TG3B: TP53 target 3B: TP53TG3C: TP53 target 3C: TP53TG3D: TP53 target 3D: TP53TG3E: TP53 target 3 family member E: The Human Protein Atlas project is funde The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way TP53 (LFS1, p53) protein expression summary. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization dom ains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism Expression of TP53 (LFS1, p53) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers
Cell atlas. Showing subcellular location of TP53 (LFS1, p53) Protein: Q9H3D4 (Uniprot-TrEMBL) TNFSF10: GeneProduct: 8743 (Entrez Gene) TP53: GeneProduct: 7157 (Entrez Gene) TP63: GeneProduct: 8626 (Entrez Gene) TP73 Delta Np73: Protein: O15350 (Uniprot-TrEMBL) TP73: GeneProduct: 7161 (Entrez Gene) TP73alpha: Protein: O15350 (Uniprot-TrEMBL) TP73beta: Protein: O15350 (Uniprot-TrEMBL) TP73delta: Protein.
UniProt Ensembl HGNC Table of contents. Somatic Somatic disease relevance of TP53. NF-kappaB/rel proteins, tumor suppressor p53, and oncogene c-Myc are critical transcription factors involved in coordinating cellular decision-making events in response to external stimuli n/a Ensembl n/a n/a UniProt n/a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Breast cancer-related regulator of TP53 is a protein that in humans is encoded by the BCPR gene. References ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Entrez Gene: Breast. TP53 tumor protein p53 [ Homo sapiens (human) ] Gene ID: 7157, updated on 8-Apr-2021. Download Datasets Summary. Go to the top of the page Help. Official Symbol TP53 provided by HGNC Official.
For this comparison, we used the datasets of UniProt human and non-human protein variants, which were introduced in the previous section, and experimental datasets from mutagenesis experiments previously carried out for the E.coli LacI protein and the human tumor suppressor TP53 protein. For the combined UniProt human and non-human protein. The standard classification used to define the various cancer genes confines tumor protein p53 (TP53) to the role of a tumor suppressor gene. However, it is now an indisputable fact that many p53 mutants act as oncogenic proteins. This statement is based on multiple arguments including the mutation Reference sequences used to annotate TP53 gene variations. Graphical view of the Genomic sequence (hg38) with exon-intron boundaries for the main p53 isoform.; Coding and protein sequence with residue numbers, amino-acids, highlighted CpG sites and exon-intron boundaries.; NCBI link to cDNA sequence corresponding to the NM_000546 isoform.; Other links to human sequence TP53 mutations are potential prognostic markers that can be used to further improve the accuracy of predicting survival and disease-free survival times of cancer patients. J Cancer Res Clin Oncol . 2019 Mar;145(3):625-636. doi: 10.1007/s00432-018-2817-z
UniProt Version: 20.1 Atlas updated: 2021-02-24 release history Proteome analysis based on 26941 antibodies targeting 17165 unique proteins TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Osteogenic Sarcoma. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and Bladder cancer IARC TP53 Database: knowledgebase and statistical tools for the analysis of TP53 gene mutations in human cancer The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA
p53 Protéine p53 complexée à un segment d' ADN (PDB 1TUP). Caractéristiques générales Nom approuvé Tumor Protein 53 Symbole TP53 Homo sapiens Locus 17 p 13.1 Masse moléculaire 43 653 Da Nombre de résidus 393 acides aminés Liens accessibles depuis GeneCards et HUGO . Entrez 7157 HUGO 11998 OMIM 191170 UniProt P04637 RefSeq (ARNm) NM_000546.5 , NM_001126112.2 , NM_001126113.2 , NM. Protein (TP53) Transcript and protein aligned (ENST00000269305.8+TP53) Gene fusions TP53 is involved in 1 fusion, with the following gene: NTRK1_ENST00000392302 (1 mutation in 38 samples) Drug sensitivity data Mutations in TP53 are associated with altered sensitivity to the following 20 drugs By differential display of an SW480 colon cancer line with an inducible TP53 expression system, followed by screening a testis cDNA library and RT-PCR, Ng et al. (1999) cloned 2 splice variants of TP53TG3. The variants encode proteins of 124 and 132 amino acids that differ only at their C termini 319801 Ensembl ENSG00000078237 ENSMUSG00000038028 UniProt Q9NQ88 Q8BZA9 RefSeq (mRNA) NM_020375 NM_177003 RefSeq (protein) NP_065108 NP_795977 Location (UCSC) Chr 12: 4.31 - 4.36 Mb Chr 6: 127.09 - 127.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that. In addition to the tumor suppressor p53 protein, also termed p53α, the TP53 gene produces p53β and p53γ through alternative splicing of exons 9β and 9γ located within TP53 intron 9. Here we report that both TG003, a specific inhibitor of Cdc2-like kinases (Clk) that regulates the alternative splicin
Little is known about TP53 mutations in Waldenström Macroglobulinaemia (WM). We evaluated 265 WM patients for TP53 mutations by next-generation sequencing, and validated the findings by Sanger sequencing. TP53 mutations were identified and validated in 6 (2·6%) patients that impacted the DNA-binding UniProt strives to provide comprehensive literature citations on which UniProtKB protein annotations are based, e.g. currently, there are ∼218 000 PubMed citations annotated in ∼4.1 million UniProtKB sequences and 66% of the citations are in UniProtKB/Swiss-Prot. Various other public databases such as Entrez Gene and model organism databases (MODs), e.g. SGD, MGI also provide curated.
TP53 tumor protein p53 [ (chicken)] Gene ID: 396200, updated on 20-Aug-2020. Summary Other designations. cellular tumor antigen p53, tumor suppressor p53. GeneRIFs: Gene References Into Functions. Alcohol. Gene ID: 403869, updated on 12-Jan-2021. Summary Other designations. cellular tumor antigen p53, mutant P53 tumor suppressor protein, tumor protein p53 (Li-Fraumeni syndrome), tumor suppressor p53, tumor suppressor protein. GeneRIFs: Gene References Into Functions. We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and. KEGG Orthology (KO) [BR:ko00001] 09130 Environmental Information Processing 09132 Signal transduction 04010 MAPK signaling pathway K04451 TP53, P53; tumor protein p5 UniProtKB/Swiss-Prot is the expertly curated component of UniProtKB (produced by the UniProt consortium). It contains hundreds of thousands of protein descriptions, including function, domain structure, subcellular location, post-translational modifications and functionally characterized variants UniProt provides cross‐references to external data collections such as the underlying DNA sequence entries in the DDBJ/EMBL/GenBank nucleotide sequence databases, 2D PAGE and 3D protein structure databases, various protein domain and family characterization databases, PTM databases, species‐specific data collections, variant databases and disease databases
SUBUNIT: (Microbial infection) Interacts with cancer-associated/HPV E6 CC viral proteins leading to ubiquitination and degradation of TP53 giving CC a possible model for cell growth regulation. This complex formation CC requires an additional factor, E6-AP, which stably associates with TP53 CC in the presence of E6 TP53 Alternative name P53. Family. Family. p53. History. neXtProt Integrated 2010-03-22 Complete UniProtKB history. Entry whose protein(s) existence is based on evidence at protein level. There is no function information available in neXtProt for NX_P04637 . Suggestions for ---uniprot-keyword--generic-phenotype---mammalian-phenotyp Human TP53 coding and protein sequence with exon boundaries in blue and CpG sites in red. Ref sequence: SwissProt #P04637.. Note that at codon position 72 (polymorphic site), CCC (Pro) is used in the new genomic reference sequence while CGC(Arg) is indicated here
TP53 / p53 Protein LS-G30747 is a Recombinant Human TP53 / p53 produced in Wheat Germ Extract with GST tag(s) Although TP53 Arg290His did not appear to affect protein activity in vitro, it did result in lower protein levels, leading the authors to suggest that maybe this allele contributed to the severe phenotype in this child (Quesnel 1999) TP53 Val203Met occurs at a position that is highly variable across species and is located in the DNA binding domain and the region required for interaction with ZNF385A, FBXO42, and AXIN1 (UniProt). In silico analyses are inconsistent regarding the effect this variant may have on protein structure and function
, mainly apoptotic cell death TP53 Cys275Tyr occurs at a position that is conserved across species and is located in the DNA binding domain and region of interaction with multiple proteins (UniProt). In silico analyses predict that this variant is probably damaging to protein structure and function Tumor proteins p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), are encoded by homologous genes in various organisms such as TP53 (humans) and Trp53 (mice)
. The cancer tissue page shows antibody staining of the protein in 20 different cancers. UniProt. Protein class. Gene ontology. Length & mass. Signal peptide (predicted) Transmembrane regions (predicted) TP53-001 ENSP00000269305 ENST00000269305 SWISS-MODEL Repository entry for Q12888 (TP53B_HUMAN), TP53-binding protein 1. Homo sapiens (Human
Blocking Peptide & Immunogen Protein. To order the blocking peptide or the immungen protein ($99 / 1mg) for Anti-p53 (phospho-S315) TP53 Antibody A00001S315, contact [email protected] for a quote. Or use the live chat function Exercise: mapping other database identifiers to UniProt. Scenario. You are helping colleagues analyse the protein products of the gene tp53 in different organisms. They have sent you a list of gene accessions that they are interested in Scenario You are helping colleagues analyse the protein products of the gene tp53 in different organisms. They have sent you a list of gene accessions that they are interested in. They are interested in analysing the corresponding protein products for these genes. Genes X9995
.org, TP53 is expressed in epithelium of mammary gland, colon, kidney, lung carcinoma, blood, ovarian adenocarcinoma, glial cell glial tumor, embryonic kidney, among other tissues. Regarding which tissues have TP53 expression, here are a few articles citing expression in various tissues: Colon, Pubmed ID: 1613161 Somatic disease relevance of TP53. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas.; Human adenocarcinomas commonly harbor mutations in the KRAS and MYC proto-oncogenes and the TP53 tumor suppressor gene.; The TP53 tumour suppressor is often mutated in a subset of astrocytomas that develop at a young age and progress slowly to glioblastoma. Blocking Peptide & Immunogen Protein. To order the blocking peptide or the immungen protein ($99 / 1mg) for Anti-Phospho-p53 (S20) TP53 Antibody A00001S20-1, contact [email protected] for a quote. Or use the live chat function Das Protein p53 ist in vielen Typen von entarteten Zellen in erhöhter Menge messbar. Es ist auch in normal wachsenden Zellen vorhanden. In ruhenden Zellen ist p53 jedoch kaum oder gar nicht zu finden. In vielen Tumortypen ist das für p53 kodierende Gen mutiert.In manchen, aber nicht allen Tumoren, scheint das Protein als Tumorsuppressor zu wirken. p53 spielt eine Rolle bei der Regulation des.
TP53 protein expression was assessed immunohistochemically in 21 nonfamilial, nonampullary small intestinal adenocarcinomas, and overexpression was demonstrated in 5 (24%). Arai et al. (1997) had previously demonstrated TP53 overexpression in 8 (53.3%) of 15 small intestinal adenocarcinomas and found missense mutations in 4 of these DGIdb, The Drug Gene Interaction Database, is a research resource that can be used to search candidate genes or drugs against the known and potentially druggable genome
.It contains protein sequences databases . History. PIR was established in 1984 by the National Biomedical Research Foundation (NBRF) as a resource to assist researchers and customers in. This will use the official API to lookup the UNIPROT_ID. To skip the lookup or use other species, specify the UniProt ID with -U (e.g. -U P04637 for TP53) Protein changes. Currently only point mutations are supported, and may be specified as: <AMINO><CODON><AMINO><#COLOR><@COUNT>